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let sealed = seal(&master_key, secret.as_bytes()).unwrap();

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Hybrid methods, as their name suggest, make use of short reads to correct errors in long reads. By finding similar regions between the short and long reads we can use the higher accuracy of short reads to correct the long ones. This is implemented in many pieces of software proovread82, Jabba83, PBcR84 or LoRDEC85. Short reads can also be used to polish long read assemblies with tools like Pilon86. The first complete human genome was assembled and polished using many different sequencing technologies including PacBio, ONT and Illumina technologies4.

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